Reviewed by Ed Kauffman, Board-Certified Nurse Practitioner
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A Guide to Semaglutide and Weight-Loss Medications

Semaglutide is gaining attention as a powerful tool for weight loss management, but how does it actually work? What results can you expect, and how does it compare to other medications like tirzepatide (Mounjaro)? Here’s what you need to know:

• What semaglutide is and how it works
• Approved vs. off-label uses for weight loss
• Real-world effectiveness
• Health benefits beyond weight loss
• Side effects, risks, and who it’s for
• How it compares to other medications
• How to find semaglutide treatment in Vancouver, WA

What Is Semaglutide?

Semaglutide is a GLP-1 receptor agonist—a type of medication that mimics a natural hormone in your body to help regulate appetite and blood sugar. Originally developed to treat type 2 diabetes, semaglutide is now FDA-approved for weight loss in its higher-dose form under the brand name Wegovy. You may also know it by its other names, Ozempic and Rybelsus (oral).

Source: FDA – Wegovy Approval

How Does Semaglutide Work for Weight Loss?

Semaglutide slows down digestion and enhances feelings of fullness, helping people eat less and lose weight sustainably. It also helps regulate blood sugar and insulin response, which can reduce fat storage.

Dosing & Forms

• Wegovy: Weekly injection approved specifically for weight loss
• Ozempic: Weekly injection originally approved for diabetes, used off-label for weight loss
• Rybelsus: Oral version, primarily for blood sugar control

How Effective Is Semaglutide for Weight Loss?

In clinical trials, participants lost up to 15–20% of their body weight over 68 weeks. However, in real-world settings, results may vary based on consistency, side effects, and access to follow-up care.

Source: NEJM – Once-Weekly Semaglutide Study

Clinical vs. Real-World Results

Many people experience meaningful weight loss on semaglutide, especially when combined with lifestyle changes. Real-world results average closer to 10–12% weight loss. Regaining weight after stopping the medication is common unless supported by ongoing changes.

Benefits Beyond Weight Loss

• Improved blood sugar control
• Reduced risk of developing type 2 diabetes
• Potential cardiovascular benefits
• Positive effects on metabolic and liver health

Source: American Diabetes Association – 2023 Guidelines

Side Effects & Safety Considerations

Common Side Effects

• Nausea
• Diarrhea
• Constipation
• Headache

Less Common Risks

• Gallstones
• Pancreatitis
• Dehydration

Who Should Not Take Semaglutide?

Semaglutide is not recommended for individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2). Discuss any current medications or conditions with a provider to ensure safety.

Comparing Semaglutide to Other Weight-Loss Medications

Semaglutide vs. Tirzepatide (Mounjaro/Zepbound)

Tirzepatide is another injectable weight-loss medication that targets two hormone receptors (GLP-1 and GIP), potentially leading to higher weight loss than semaglutide. However, it is newer and not yet approved solely for weight loss under all brands.

Semaglutide vs. Phentermine, Orlistat, and Others

Older medications like phentermine or orlistat tend to offer more modest results—typically 3–7% total body weight reduction—and come with their own risks and limitations.

Semaglutide vs. Lifestyle Changes Alone

Lifestyle changes (diet, movement, sleep) remain foundational. However, for those struggling to lose weight with lifestyle adjustments alone, semaglutide can significantly improve outcomes.

Choosing the Right Weight-Loss Approach

Is Semaglutide Right for You?

Semaglutide may be appropriate for individuals with a BMI over 30, or over 27 with related health conditions (like hypertension or prediabetes). If you’ve tried lifestyle changes without lasting results, a medication-supported approach may help.

Considerations

• Ongoing access to care and monitoring
• Insurance coverage or out-of-pocket costs
• Managing side effects

What Does Semaglutide Cost?

Semaglutide costs vary depending on insurance coverage, brand (Wegovy vs. Ozempic), and pharmacy. Some plans may partially or fully cover the medication, while others may not.

VDPC patients receive personalized cost guidance and support in accessing the most affordable options. If your insurance does not cover semaglutide, using a compounding pharmacy costs between $105 to $200 per month depending on the dose. 

Get a Professional Medical Recommendation

The safest and most effective weight-loss plan starts with expert guidance. Our team at Vancouver Direct Primary Care offers semaglutide in Vancouver, WA and can help you determine if it’s the right option for you.