Best Weight Loss Medications for 2025

Whether you’re just starting your journey or reevaluating your current plan, understanding which medications are most effective – and most accessible – can help you make a confident, informed decision.

In this article we’ll cover:

• • Top GLP-1 and GIP medications for weight loss in 2025
  • How each medication works and what it’s best for
  • Side effects and tolerability
  • New medications gaining attention in 2025
  • How to choose the right option for your body and goals
  • Where to access trusted care and ongoing support

Top Weight Loss Medications in 2025

Based on clinical research, real-world outcomes, and patient demand, here are the top contenders for best weight loss medications in 2025:

GLP-1 and GIP Agonists

Wegovy (semaglutide)

• Wegovy (semaglutide) remains the gold standard for weight loss in 2025, with consistent clinical results showing 10–15% body weight reduction. It is FDA-approved and widely prescribed for patients with a BMI ≥30 or ≥27 with weight-related conditions.

Zepbound (tirzepatide)

• As the first dual GIP and GLP-1 receptor agonist approved for weight loss, Zepbound has shown up to 22% weight loss in trials. It may offer faster results but can cause more gastrointestinal side effects.

Ozempic (semaglutide, off-label)

• Although FDA-approved for type 2 diabetes, Ozempic is commonly used off-label for weight loss when Wegovy is unavailable or not covered by insurance.

Mounjaro (tirzepatide, off-label)

• Before Zepbound was approved, Mounjaro was the go-to off-label tirzepatide prescription for weight loss. Many patients still use it with success, especially if covered by insurance plans.

Related Articles: How Semaglutide Compares  to Alternatives

Non-GLP Medications

Contrave (naltrexone/bupropion)

• This combination medication works on the brain’s reward system to reduce food cravings and emotional eating. It’s often used for patients who cannot tolerate injectables or have contraindications for GLP-1 therapy.

Qsymia (phentermine/topiramate)

• Qsymia combines a stimulant with a medication used for migraines and epilepsy. It’s FDA-approved for weight loss and may suit patients seeking oral medications that support appetite suppression and increased energy expenditure.

Orlistat (Alli, Xenical)

• A fat absorption inhibitor available OTC and by prescription, orlistat blocks about 25% of dietary fat from being absorbed. It’s a budget-friendly option but usually results in less dramatic weight loss (~5%).

Compounded GLP-1s

Compounded semaglutide or tirzepatide

• These versions are prepared by compounding pharmacies and may be prescribed when branded medications aren’t accessible or affordable. While not FDA-approved, they may be beneficial when sourced and supervised properly.

New and Emerging Medications in 2025

In Development

Several new injectable and oral options are in late-stage clinical trials as of 2025, including once-monthly formulations and GLP-1 hybrids with enhanced tolerability. These next-gen compounds aim to reduce nausea and improve metabolic markers.

What to Watch For

Keep an eye on press releases and updates from the FDA, Novo Nordisk, Eli Lilly, and other major pharmaceutical companies as new treatments continue to expand options for patients and providers alike.

How Do These Medications Actually Work?

GLP-1 & GIP Receptor Agonists

These mimic natural hormones that regulate hunger and insulin response. They slow gastric emptying, reduce cravings, and improve insulin sensitivity.

Appetite Suppressants

Stimulant-based or neuroactive medications like phentermine or Contrave work centrally to reduce food-related impulses and overeating behavior.

Fat Absorption Inhibitors

Orlistat prevents the body from absorbing dietary fat. It does not suppress appetite but can be effective when paired with a low-fat diet.

What Are the Side Effects of Weight Loss Medications?

Common Across Most Medications

• Nausea
• Constipation or diarrhea
• Headaches or fatigue (especially early on)

Medication-Specific Reactions

GLP-1s may cause vomiting or bloating during dose titration. Contrave can cause anxiety or dry mouth. Qsymia may raise heart rate or cause insomnia. Orlistat is known for GI issues if dietary fat intake is high.

Who Should Not Take These Medications?

Medical Contraindications

People with a history of pancreatitis, thyroid cancer, certain mood disorders, or cardiovascular disease may not be suitable candidates for all medications. Always check with your provider before starting a new regimen.

Medication Interactions

GLP-1s may alter absorption of oral contraceptives. Contrave may not be suitable for individuals on SSRIs. Discuss all current medications with your provider during consultation.

Best Weight Loss Medication by Category

There’s truly no single “best” medication for everyone. Your ideal option depends on your goals, health profile, side effect tolerance, and insurance. Some patients respond better to appetite suppression; others need metabolic support or blood sugar regulation.  Here’s a look at how some of these medications stack up – but ultimately, VDPC recommends working with a licensed medical professional to determine what’s best for you.

• Best Overall: Wegovy or Zepbound
• Best for Insurance Access: Ozempic or Mounjaro
• Best Budget Option: Orlistat or compounded semaglutide
• Best for Appetite Cravings: Contrave
• Best GLP-1 Alternative: Qsymia

How to Choose the Right Weight Loss Medication

Working with a medical provider can help you evaluate what’s safe, effective, and sustainable for your unique needs. At VDPC, we specialize in helping patients understand these options and find the right path forward—based on real outcomes, not marketing hype.

Start Your Journey with Support

If you’re ready to explore your options with expert help, Vancouver Direct Primary Care is here to guide you. Our team stays up-to-date on emerging treatments, understands how to navigate insurance, and puts your goals at the center of your plan.